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Updated: May 30, 2025

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Platforms for the Search for New Antimicrobial Agents Using In Vivo C. elegans Models.

A I Kalganova1, I E Eliseev1, I V Smirnov1,2,3

  • 1Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, 117997 Russian Federation.

Acta Naturae
|January 29, 2025
PubMed
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Developing novel antimicrobial drugs is crucial. The microscopic nematode Caenorhabditis elegans (C. elegans) offers a promising model for studying host-pathogen interactions and discovering new anti-infective compounds.

Area of Science:

  • Microbiology and Infectious Diseases
  • Drug Discovery and Development
  • Model Organism Research

Background:

  • Current high-throughput screening methods for antimicrobial drugs are limited.
  • Traditional in vitro pathogen cultures do not fully capture host-pathogen dynamics.
  • In vivo testing in chordate models is costly and unsuitable for primary screening.

Purpose of the Study:

  • To address the need for effective platforms for antimicrobial drug discovery.
  • To explore the utility of Caenorhabditis elegans (C. elegans) as a model for host-pathogen interactions.
  • To identify novel anti-infective compounds with new mechanisms of action.

Main Methods:

  • Utilizing the microscopic nematode C. elegans to model human infections.
Keywords:
C. elegansantimicrobialsdrug discoveryinfection modelmicrofluidicspathogens

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  • Investigating host-pathogen interactions within the C. elegans model.
  • Screening compounds for antimicrobial activity using the C. elegans infection model.

    • Main Results:

    • C. elegans serves as a viable model for studying host-pathogen interactions.
    • This model facilitates the identification of anti-infective compounds.
    • The approach allows for the discovery of compounds with novel mechanisms of action.

    Conclusions:

    • The microscopic nematode C. elegans presents a promising and accessible platform for antimicrobial drug discovery.
    • This model system enables detailed investigation of host-pathogen interactions.
    • C. elegans-based screening can identify compounds targeting virulence factors and with reduced organ toxicity.