Related Experiment Video
Updated: May 30, 2025
09:30
A Microcontroller Operated Device for the Generation of Liquid Extracts from Conventional Cigarette Smoke and Electronic Cigarette Aerosol
Published on: January 18, 2018
8.3K
Electronic cigarettes for smoking cessation
Nicola Lindson1, Ailsa R Butler1, Hayden McRobbie2
1Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
The Cochrane Database of Systematic Reviews
|January 29, 2025
Summary
Electronic cigarettes (ECs) with nicotine significantly increase smoking cessation rates compared to nicotine replacement therapy (NRT) and non-nicotine ECs. While generally safe, more research is needed to fully assess long-term safety.
Area of Science:
- Public Health
- Clinical Trials
- Evidence-Based Medicine
Background:
- Electronic cigarettes (ECs) are vaping devices used to deliver nicotine.
- There is ongoing debate regarding their efficacy and safety for smoking cessation.
- This review is an update of a living systematic review on ECs for smoking abstinence.
Purpose of the Study:
- To evaluate the safety, tolerability, and effectiveness of nicotine ECs for long-term smoking abstinence.
- Comparisons include non-nicotine ECs, other smoking cessation treatments, and no treatment.
Main Methods:
- Systematic review including randomized controlled trials (RCTs) and uncontrolled intervention studies.
- Searches conducted across major databases up to February 2024.
- Risk of bias and GRADE assessments used; meta-analyses performed for pooled data.
Main Results:
- High-certainty evidence shows nicotine ECs increase quit rates versus NRT (RR 1.59).
- Moderate-certainty evidence shows nicotine ECs increase quit rates versus non-nicotine ECs (RR 1.46).
- Adverse events (AEs) rates were similar between nicotine ECs and NRT/non-nicotine ECs; low-certainty evidence suggests higher AEs versus behavioral support.
Conclusions:
- Nicotine ECs are effective for smoking cessation, with high-certainty evidence supporting their use over NRT.
- No evidence of serious harm detected, but longer-term safety requires further investigation.
- The review is ongoing, with monthly searches to incorporate new evidence.
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