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Updated: May 30, 2025

Tissue Triage and Freezing for Models of Skeletal Muscle Disease
Published on: July 15, 2014
Disorders of Muscle Mass and Tone
1SVM: Department of Medicine and Epidemiology, University of California, Davis, Tupper Hall 2108, One Shields Avenue, Davis, CA 95616, USA.
Abstract:
Muscle disease has various clinical manifestations that range from exertional and non-exertional rhabdomyolysis, fasciculations, weakness, rigidity, stiffness, gait abnormalities, poor performance, and alterations in muscle mass and tone. Neurogenic disorders and non-neurogenic disorders such as primary muscle disease can cause muscle atrophy and changes in muscle tone. Myotonic disorders can have a genetic (eg, inherited channelopathies) or acquired (eg, electrolyte derangements) origin. Normal muscle enzyme activities do not rule out a myopathic disorder as the underlying cause of muscle atrophy and changes in muscle tone. Genetic testing to facilitate responsible breeding practices is recommended.
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