Photoredox-Mediated Radical Addition/Cyclization To Construct Benzannulated 6,5-Spiroketal Glycosides
Chen Li1, Shouyun Yu1,2
1State Key Laboratory of Analytical Chemistry for Life Science, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
Abstract:
We herein present a green and mild photoredox strategy for constructing a framework of benzannulated 6,5-spiroketal glycosides. This method employs various O-arylacetylene glycosides and aryl ketone acids as the starting materials, facilitating the rapid and straightforward synthesis of 6,5-spiroketal glycosides with up to 92% yields under photoredox catalytic conditions. This efficient approach has the potential to significantly enhance the molecular library of carbohydrate-based pharmaceuticals.
More Related Videos
05:34Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
07:12Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Related Concept Videos
Cyclohexenones via Michael Addition and Aldol Condensation: The Robinson Annulation
Radical Formation: Addition
Similar to charge conservation in chemical reactions, spin conservation is implicit for radical reactions. Accordingly, the product formed must possess an...
Cycloaddition Reactions: Overview
Benzene to 1,4-Cyclohexadiene: Birch Reduction Mechanism
Photochemical Electrocyclic Reactions: Stereochemistry
Selection Rules: Photochemical Activation
Diels–Alder Reaction Forming Cyclic Products: Stereochemistry
