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Related Concept Videos

Local Anesthetics: Common Agents and Their Applications01:23

Local Anesthetics: Common Agents and Their Applications

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Local anesthetics (LAs) are commonly used for various applications in medical and dental procedures. Some of the common agents used are cocaine, lidocaine, and bupivacaine.
Cocaine is an ester of benzoic acid and methylecgogine. It is used to anesthetize and vasoconstrict locally. Currently, it is used primarily for topical applications. It is beneficial for surgeries on the upper respiratory tract, providing anesthesia and shrinking the mucosa. Cocaine in the form of cocaine hydrochloride is...
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Inhalational Anesthetics: Overview01:20

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Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...
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Depending on the target organ, local anesthetics (LAs) can be administered via various routes. In surface anesthesia, LAs are applied directly to the surface of the skin or mucous membranes. It is widely used for topical skin numbing before venipuncture or minor surgical procedures. Commonly used surface local anesthetics are lidocaine or benzocaine sprays or creams. Surface anesthesia occurs within 5 minutes and lasts for about 60 minutes. One of the main disadvantages of topical anesthesia is...
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Local Anesthetics: Adverse Effects01:12

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While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
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General Anesthesia: Overview01:24

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Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
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The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
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Updated: May 29, 2025

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Topical intranasal anesthesia impairs trigeminal function and airflow perception.

C Migneault-Bouchard1, F J M Boselie2, J Frasnelli3

  • 1Department of Anatomy, Universite du Quebec Trois-Rivieres (UQTR), Trois-Rivieres, QC, Canada.

Rhinology
|February 2, 2025
PubMed
Summary
This summary is machine-generated.

Topical intranasal anesthesia reduced trigeminal sensitivity, leading to a subjective decrease in nasal patency. This finding suggests a link between trigeminal nerve function and the sensation of nasal obstruction.

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Area of Science:

  • Otorhinolaryngology
  • Neuroscience
  • Sensory Science

Background:

  • Chronic nasal obstruction (CNO) may stem from impaired airflow perception by the intranasal trigeminal system.
  • This is particularly relevant when anatomical or inflammatory causes are absent.

Purpose of the Study:

  • To investigate the impact of topical intranasal anesthesia on intranasal trigeminal sensitivity.
  • To determine the subsequent effect on the subjective sensation of nasal obstruction.

Main Methods:

  • A randomized crossover study involving 16 healthy subjects.
  • Assessment of trigeminal sensitivity using the Trigeminal Lateralization Task (TLT) with eucalyptol.
  • Objective (Peak Nasal Inspiratory Flow) and subjective (VAS, ENS6Q, NOSE) measures of nasal patency.

Main Results:

  • Topical intranasal anesthesia significantly diminished intranasal trigeminal sensitivity.
  • Reduced trigeminal sensitivity correlated with subjectively decreased nasal patency, as indicated by ENS6Q and NOSE scores.

Conclusions:

  • Intranasal anesthesia impairs trigeminal nerve function, resulting in a reduced perception of nasal airflow.
  • Further research is needed to explore the relationship between trigeminal function and subjective nasal obstruction for potential therapeutic interventions.