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Updated: May 29, 2025

Quantifying Infra-slow Dynamics of Spectral Power and Heart Rate in Sleeping Mice
Published on: August 2, 2017
Future of Sleep Medicine: Novel Approaches and Measures Derived from Physiologic Systems Dynamics (Part I)
Plamen Ch Ivanov1, Ronny P Bartsch2
1Keck Laboratory for Network Physiology, Department of Physics, Boston University, Boston, MA 02215, USA; Institute of Solid State Physics, Bulgarian Academy of Sciences, Sofia 1784, Bulgaria.
Abstract:
We review recent progress in understanding fundamental aspects of physiologic regulation during wake and sleep based on modern data-driven, analytical, and computational approaches with a focus on the complex dynamics of individual physiologic systems. The presented empirical findings indicate that sleep-wake and circadian cycles do not simply modulate basic physiologic functions but influence physiologic systems dynamics simultaneously over a broad range of time scales. The reviewed empirical approaches and derived measures represent novel mechanistic aspects of sleep and wake regulation, and lay the foundation for a new class of diagnostic and prognostic biomarkers in clinical sleep medicine.
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