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Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach

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[The interaction between plasma aluminum concentration and schooling year on cognitive function].

L M Ma¹, Y J Xue¹, X Y Li¹

¹Department of Occupational Health, School of Public Health, Shanxi Medical University, Taiyuan 030001, China.

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi = Zhonghua Laodong Weisheng Zhiyebing Zazhi = Chinese Journal of Industrial Hygiene and Occupational Diseases

|February 5, 2025

Summary

Aluminum exposure is linked to cognitive impairment, with higher exposure increasing risk. Low schooling year significantly amplifies this risk, highlighting a critical interaction for early detection and prevention strategies.

Keywords:

Aluminum Clock-drawing test Cognitive function Education Mini-mental state examination Plasma Transactional analysis

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Area of Science:

Occupational Health and Toxicology
Neuroscience and Cognitive Function

Context:

Investigated 1114 aluminum-exposed workers to assess the impact of plasma aluminum concentration on cognitive function.
Utilized inductively coupled plasma-mass spectrometry (ICP-MS) for accurate plasma aluminum level measurement.
Employed mini-mental state examination and clock drawing test to evaluate cognitive performance.

Purpose:

To determine the relationship between plasma aluminum concentration and cognitive function in exposed workers.
To analyze the interaction effect of plasma aluminum levels and schooling year on cognitive impairment.
To provide a basis for early identification of cognitive damage caused by aluminum exposure.

Summary:

A significant dose-response relationship was found between plasma aluminum concentration and cognitive impairment.
Higher plasma aluminum levels correlated with decreased cognitive scores and increased risk of impairment.
A significant interaction was identified between plasma aluminum concentration and low schooling year, amplifying cognitive risk.

Impact:

Findings underscore the detrimental effect of aluminum exposure on cognitive function, particularly in individuals with lower educational attainment.
Highlights the importance of considering combined exposure and educational level for risk assessment and targeted interventions.
Provides crucial data for developing preventive measures and occupational health guidelines for aluminum-exposed workers.