A Multi-Component Reaction Peptide Augmenting the Anti-Aging Benefits of Non-Ablative Laser Procedure

Laser resurfacing is one of the most popular aesthetic procedures that address a wide range of skin conditions and overall skin rejuvenation. To reduce downtime and improve the clinical efficacy of the procedures, it is important to design post-procedure care routines to complement them. Towards fulfilling that consumer need, a peptide synthesized from multi-component reaction (MCP) has been developed.

 The objective of this study is to investigate the functionalities of MCP as a regenerative active that enhances the healing kinetics and anti-aging performance following non-ablative fractional laser resurfacing procedures.

 To fulfill the objective, a single-center, split-face design, double-blinded, randomized clinical study was conducted. Study participants received a full face non-ablative fractional laser procedure followed by treatment with two topical products, MCP formula or Aquaphor Healing Ointment®or AHO (Beiersdorf Inc, Wilton, CT) as a standard of care topical agent. Both products were applied immediately after the laser procedure and continued two times daily for 28 days. Clinical evaluation and expert grading of healing and aging, instrument measurement of skin barrier function, optical coherence tomography and standardized digital imaging were performed.

 Clinical evaluation results showed that the MCP formula promoted post-procedure skin healing at a comparable level as Aquaphor Healing Ointment®. However, the MCP formula demonstrated faster kinetics and enhanced level of improvement in multiple anti-aging parameters when compared with the benchmark control. Results from this clinical study demonstrate that the use of MCP formula post non-ablative fractional laser treatment is efficacious in promoting skin healing and enhancing the anti-aging benefits provided by the procedure. J Drugs Dermatol. 2025;24(2):188-195. doi:10.36849/JDD.8066R1.