Perspective: Advancing the science regarding temporomandibular disorders.

Area of Science:

• Multidisciplinary research
• Systems biology
• Musculoskeletal conditions

Background:

• Temporomandibular Disorders (TMDs) are complex musculoskeletal conditions.
• The National Academies of Sciences, Engineering, and Medicine (NASEM) called for improved TMD research.
• Existing research and clinical practice require better integration.

Purpose of the Study:

• To emphasize the critical role of systems biology in advancing Temporomandibular Disorders (TMD) research.
• To address the NASEM recommendations for broadening TMD research scope.
• To improve the integration of basic and clinical sciences for TMDs.

Main Methods:

• Analysis of three publications within a Special Issue.
• Focus on laboratory research and clinical observation domains.
• Synthesis of findings related to systems biology approaches for TMDs.

Main Results:

• Systems biology is essential for understanding TMDs.
• Integration of laboratory and clinical data is vital.
• Three publications underscore the need for broader, integrated TMD research.

Conclusions:

• Adopting a systems biology approach will enhance understanding of complex TMDs.
• Improved integration of basic and clinical science is necessary for better patient care.
• Clinicians should utilize existing evidence while advocating for more research to improve patient outcomes.