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Published on: November 23, 2015
Plasmonic Biosensors for Health Monitoring: Inflammation Biomarker Detection.
M Amirul Islam1, Jean-François Masson1
1Département de Chimie, Institut Courtois, Centre Interdisciplinaire de Recherche sur le Cerveau et l'Apprentissage, Quebec Center for Advanced Materials, Regroupement Québécois sur les Matériaux de Pointe, Université de Montréal, C.P. 6128 Succ. Centre-ville, Montréal, Québec H3C 3J7, Canada.
Surface plasmon resonance (SPR) biosensors offer real-time, label-free detection of disease biomarkers. Advances in nanomaterials and microfluidics enhance SPR biosensor performance for clinical diagnostics and point-of-care applications.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Analytical Chemistry
Background:
- Surface plasmon resonance (SPR) and localized SPR (LSPR) biosensors are advanced tools for clinical biomarker detection.
- These biosensors enable real-time, label-free monitoring of biomarkers in complex biological fluids.
- Nanomaterials and microfluidics have significantly improved SPR biosensor performance, specificity, and detection limits.
Purpose of the Study:
- To overview recent advancements in plasmonic biosensing for clinical diagnostics.
- To highlight the application of SPR biosensors in detecting inflammation biomarkers for various diseases.
- To explore future directions for translating SPR biosensors into clinical practice and personalized healthcare.
Main Methods:
- Review of recent breakthroughs in SPR biosensor design, nanomaterial integration (gold nanoparticles, graphene, carbon nanotubes), and surface functionalization.
- Analysis of microfluidic integration for multiplexed biomarker detection.
- Case examples using inflammation biomarkers (CRP, ILs, TNF-α, PCT, ferritin, fibrinogen) for conditions like cardiovascular diseases, autoimmune disorders, infections, and sepsis.
Main Results:
- Incorporation of advanced nanomaterials enhances SPR biosensor performance, improving detection limits, stability, and specificity.
- Microfluidic integration allows for simultaneous detection of multiple biomarkers in complex samples.
- Plasmonic biosensors show significant potential for detecting key inflammation biomarkers relevant to various diseases.
Conclusions:
- Advancements in SPR biosensing technology are bridging the gap towards clinical diagnostics and point-of-care (POC) applications.
- SPR biosensors offer enhanced diagnostic accuracy, reproducibility, and accessibility, particularly in POC settings.
- These biosensors are poised to significantly contribute to personalized healthcare through real-time, high-precision diagnostics.
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