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Published on: March 30, 2020
Favorable Outcome After Pegcetacoplan (Syfovre)-Associated Occlusive Retinal Vasculitis
Abstract:
An 86-year-old woman with advanced dry age-related macular degeneration developed occlusive retinal vasculitis 11 days after her first pegcetacoplan injection. Vision decreased from 20/30 to counting fingers. Vision improved to 20/200 with periocular and systemic steroids. Two different sets of culture plates and gram stains were all negative, but one thioglycolate broth had a light growth of Staphylococcus epidermidis and repeat vitreous culture broth grew a different organism (Staphylococcus capitis). After intravitreal steroids and ceftazidime, the vision ultimately improved to 20/20. Periocular and systemic steroids and antibiotics were associated with a favorable visual outcome in this patient. [Ophthalmic Surg Lasers Imaging Retina 2025;56:170-173.].
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