Analysis of Crystalline Lens Tilt and Decentration Using a Fully Automated Swept-Source Optical Coherence Tomography...

To evaluate the repeatability of a fully automated swept-source optical coherence tomography (SS-OCT) biometer to measure healthy crystalline lens decentration and tilt and their correlation with other biometric parameters.

In this prospective study, 135 eyes of 135 patients were included. Ocular biometric parameters including crystalline decentration and tilt were measured three times with the Eyestar 900 SS-OCT (Haag-Streit AG). The repeatability was analyzed with the within-subject standard deviation (S_w), coefficient of variability, and coefficient of repeatability. Other biometric parameters such as keratometry (K1 flat and K2 steep), anterior chamber depth (ACD), lens thickness (LT), and axial length (AL) were also analyzed to explore possible relationships.

For K1, K2, ACD, LT, and AL, S_w values were 0.07 diopters (D), 0.14 D, 0.01 mm, 0.02 mm, and 0.01 mm, respectively. For X and Y decentration and tilt, S_w values were 0.01, 0.02, and 0.39 mm, respectively. The correlation coefficient (r) between the crystalline lens tilt was low (r < -0.300) for all ocular biometric parameters, and was only associated with the AL (P < .001, r = -0.295). The r value between the decentration along the X and Y direction and the ocular biometric parameters was in all cases lower than 0.300. There was only a correlation between the decentration (Y direction) and K2 and ACD parameters (P < .001, P = .007, respectively). The linear regression parameters resulted in a slope value lower than -0.15 between any direction of the decentration and the other ocular biometric parameters.

The Eyestar 900 provides repeatable measurements for crystalline lens decentration and tilt. AL was the only biometric parameter correlated with the crystalline lens tilt, and keratometry, ACD, and LT were correlated with the crystalline lens decentration along the Y direction. [.