Nutritional Status of Vitamin E and Its Association with Metabolic Health in Adults

Vitamin E is one of the key dietary antioxidants. However, current evidence remains insufficient to establish a definitive relationship between circulating vitamin E levels, body fat content, and their influence on metabolic health. This study aimed to assess and compare the vitamin E nutritional status in adults with normal and excess body fat and its determinants.

Concentrations of vitamin E isoforms (α- and γ-tocopherols, α- and γ-tocotrienols) were assessed in 127 individuals. Body fat content and other anthropometric indices, as well as biochemical markers such as lipid profile, plasma fatty acid concentration and C-reactive protein, were identified as markers of metabolic health. Participants were divided into two groups: with normal and excess body fat (defined as more than 30% in women and more than 25% in men).

The determinants of higher α-tocopherol concentrations were lower body fat content and higher levels of circulating lipids as HDL and LDL (R² = 0.221, p < 0.001 in a model of multivariate linear regression). The level of circulating vitamin E isoforms correlated with the concentration of CRP (r = -0.464 for α-T, r = -0.453 for αT3, r = -0.270 for γ-T, r = -0.355 for γ-T3). Similarly, elevated concentrations of vitamin E isoforms are linked to lower adipose tissue content, which may contribute to lower inflammation and improved metabolic health (r = -0.359 for α-T, r = -0.333 for αT3, r = -0.276 for γ-T3, no significant correlation for γ-T).

These results reveal that the vitamin E status of adults with excess body fat may be inadequate and linked to poorer metabolic health. We found that the determinants of lower plasma vitamin E were higher BF and lower TC and its fraction, with the strongest correlations being found for HDL.