Reinforcing Nrf2 Signaling: Help in the Alzheimer's Disease Context

Area of Science:

• Neuroscience
• Biochemistry
• Pathology

Background:

• Oxidative stress is implicated in neurodegenerative diseases, notably Alzheimer's disease (AD), affecting the aging population.
• It is recognized as an early pathological marker in AD, coinciding with reduced free radical scavenging capacity in older adults.
• The Nrf2 transcription factor, crucial for antioxidant defenses, declines in both quantity and activity with age.

Purpose of the Study:

• To review natural compounds that activate the Nrf2 pathway for neuroprotection.
• To emphasize the role of Nrf2 signaling in combating oxidative stress and neurotoxicity.
• To explore a holistic approach for AD treatment and the development of Nrf2-targeting drugs.

Main Methods:

• Literature review of studies on Nrf2 pathway activation.
• Analysis of natural compounds with neuroprotective properties.
• Synthesis of information on oxidative stress mechanisms in AD.

Main Results:

• Nrf2 is a key regulator of antioxidant response.
• Natural compounds activating Nrf2 show neuroprotective effects.
• Aging impairs Nrf2 function, exacerbating AD pathology.

Conclusions:

• Nrf2 pathway activation is a promising strategy for AD prevention and treatment.
• Natural compounds offer a potential avenue for reinforcing antioxidant defenses in AD.
• Further research into Nrf2-targeting drugs is warranted for effective AD therapeutics.