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Development of multicenter consensus care plans for immunosuppression after pediatric liver transplant: Reducing variability, creating comparative efficacy opportunities.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·2026
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OPTN/SRTR 2024 Annual Data Report: Pancreas.

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OPTN/SRTR 2024 Annual Data Report: Kidney.

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Alpha-Gal Syndrome: Unrecognized Risks of a Tick-Bite-Associated Allergy in Transplantation and Cellular Therapy.

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Updated: May 28, 2025

Author Spotlight: Investigating the Effects of Compounds on Intestinal Tissue Using 3D Human Cell Line Models
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OPTN/SRTR 2023 Annual Data Report: Intestine.

Simon P Horslen1, Vikram K Raghu2, Yoon Son Ahn3

  • 1Scientific Registry of Transplant Recipients, Hennepin Healthcare Research Institute, Minneapolis, MN; Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|February 13, 2025
PubMed
Summary
This summary is machine-generated.

Intestine transplants offer significant benefits for patients with intestinal failure. In 2023, 95 transplants occurred, with varying survival rates and risks, particularly for those needing combined liver-intestine transplants.

Keywords:
Intestinal failureintestine transplantintestine-liver transplantoutcomespediatricwaiting list

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Area of Science:

  • Gastroenterology and Hepatology
  • Transplantation Medicine
  • Surgical Oncology

Background:

  • Intestine transplantation is a vital treatment for intestinal failure, often resulting from long-term parenteral nutrition complications or abdominal catastrophes.
  • Despite its critical role, intestine transplantation is infrequently performed, highlighting the need for continued research and improved outcomes.
  • The demand for intestine transplants, particularly in the adult population, has been steadily increasing over recent years.

Purpose of the Study:

  • To analyze the trends, outcomes, and complications of intestine transplantation in 2023.
  • To compare graft survival rates and patient mortality between intestine-without-liver and intestine-with-liver transplants.
  • To assess the incidence of acute rejection and post-transplant lymphoproliferative disorder (PTLD) in different transplant scenarios.

Main Methods:

  • Retrospective analysis of intestine transplant data from 2023, including waiting list additions, performed procedures, and patient demographics.
  • Evaluation of graft survival rates at 1 and 5 years for adult and pediatric recipients, stratified by transplant type (with or without liver).
  • Analysis of mortality on the waiting list and incidence of acute rejection and PTLD.

Main Results:

  • In 2023, 135 candidates were added to the waiting list, and 95 intestine transplants were performed, with 33 in pediatric recipients.
  • Graft survival varied: intestine-without-liver showed 1-year survival of 78.3% (adults) and 76.1% (pediatrics), while intestine-with-liver showed 57.8% (adults) and 81.1% (pediatrics).
  • Acute rejection occurred in ~20% of patients within the first year. 5-year PTLD incidence was higher in intestine-without-liver (11.5%) vs. intestine-with-liver (2.5%) recipients.

Conclusions:

  • Intestine transplantation remains a critical therapy, but outcomes differ significantly based on whether a liver is included.
  • While waiting list mortality is low for intestine-without-liver transplants, it exceeds 10% for those awaiting intestine-with-liver transplants.
  • Long-term graft survival and complication rates necessitate ongoing research, especially considering advances in intestinal rehabilitation and the growing adult recipient pool.