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Updated: May 28, 2025
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Published on: March 23, 2011
Effect of Myelopeptide MP5 on Synaptic Plasticity of the Hippocampus during Addictive Memory Extinction in C57BL/6
N A Beregovoy1, G K Volcho2, M V Starostina2
1Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia. n_bergg@mail.ru.
Abstract:
The rapid formation and high stability of addictive memory are the main causes of frequent relapse of alcohol and drug diseases, which limits the possibility of complete recovery and necessitates the search for ways to disrupt the formation or enhance the extinction of addictive memory. The present work shows that myelopeptide MP5 accelerates the extinction of morphine-induced conditioned place preference in C57BL/6 mice and supports synaptic plasticity in the hippocampus, while MP2 produced no such effects.
