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Preparation of Mouse Pituitary Immunogen for the Induction of Experimental Autoimmune Hypophysitis
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A Rare Case of Microscopic Polyangitis With Associated Transient Hypophysitis.
Mercedes Martinez-Gil1, Monica Rodriguez2, Jeremy Hughes3
1Department of Internal Medicine, Creighton University School of Medicine, Phoenix, AZ 85013, USA.
JCEM Case Reports
|February 14, 2025
Summary
Microscopic polyangiitis (MPA), a rare vasculitis, can cause pituitary enlargement. This case report details a successful treatment of pituitary mass effect due to MPA using prednisone and rituximab.
Area of Science:
- Rheumatology
- Endocrinology
- Neurology
Background:
- Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are rare antineutrophil cytoplasmic antibody-associated vasculitides.
- These conditions cause systemic inflammation and small blood vessel necrosis, potentially leading to multiorgan damage.
- MPA is characterized by necrotizing vasculitis and myeloperoxidase (MPO) positivity, distinguishing it from GPA.
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