Epigenetics Modulators as Therapeutics for Neurological Disorders
Mansi Gaba1, Ashwani Sharma2, Nitin Chitranshi3
1School of Pharmaceutical Sciences, MVN University, Palwal, Haryana, India.
Current Pharmaceutical Design
|February 14, 2025
Summary
Epigenetic mechanisms influence neurological disorders. Epigenetic therapies show promise for treating conditions like Alzheimer's and Parkinson's by targeting gene expression, but challenges remain.
Area of Science:
- Neuroscience
- Molecular Biology
- Genetics
Background:
- Epigenetic mechanisms (DNA methylation, histone modification, non-coding RNAs) are vital for gene expression and neural plasticity.
- Dysregulation of these epigenetic processes is implicated in the pathogenesis of neurological disorders such as Alzheimer's disease, Parkinson's disease, and epilepsy.
Purpose of the Study:
- To review recent findings on epigenetic therapies for neurological disorders.
- To discuss the potential benefits and challenges of using epigenetic modulators in clinical settings.
Main Methods:
- Review of current clinical trials and research on epigenetic modulators.
- Analysis of epigenetic mechanisms including DNA methyltransferase and histone deacetylase inhibitors.
Main Results:
- Epigenetic modulators offer a promising strategy to correct aberrant epigenetic marks and restore neurological homeostasis.
- These interventions have the potential to halt or reverse disease progression, offering targeted and neuroprotective effects.
Conclusions:
- Epigenetic therapies present a novel approach for treating neurological disorders.
- Key challenges include ensuring specificity, effective delivery, and long-term efficacy of these treatments.
Keywords:
DNA methylationEpigeneticsepigenetic modulatorshistone modificationneurological disorderstherapeutic interventions.More Related Videos
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