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Updated: May 27, 2025

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
Published on: December 13, 2017
The thalamus: Structure, function, and neurotherapeutics
Lara V Marcuse1, Mackenzie Langan2, Patrick R Hof3
1Department of Neurology, Epilepsy Division, Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, 1000 10th Ave, New York, NY 10019, USA.
Abstract:
The complexity and expansive nature of thalamic research has led to numerous interventions for varied disease states. At the same time, this complexity along with siloed areas of study can hinder a comprehensive understanding. The goal of this paper is to give the reader a broader and more detailed perspective on the thalamus. In order to accomplish this goal, the paper begins with a summary of the function, electrophysiology, and anatomy of the normal thalamus. With this foundation, thalamic involvement in neurological diseases is discussed with a focus on epilepsy. Therapeutic interventions in the thalamus for epilepsy as well as movement disorders, psychiatric conditions and disorders of consciousness are described. Lastly limitations in the field and future models of data sharing and cooperation are explored.
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