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Updated: May 27, 2025
A Protocol to Set Up Needle-Free Connector with Positive Displacement on Central Venous Catheter in Intensive Care Unit
Published on: July 13, 2019
Innovative dual-contrast nanocoating for central venous catheters: prolonged infection resistance and enhanced
Hasti Tashak Golroudbari1, Somayeh Mojtabavi1, Mostafa Mohammadi2
1Department of Pharmaceutical Biotechnology, Faculty of Pharmacy and Biotechnology Research Center, Tehran University of Medical Sciences, P.O. Box 14155-6451, Tehran 1417614411, Iran. faramarz@tums.ac.ir.
Abstract:
Central venous catheter (CVC) related bacteremia is an essential cause of hospital infections associated with morbidity, mortality, and healthcare costs. Recent advancements in catheter coatings have demonstrated an effective strategy for preventing microbial colonization and biofilm formation. In this study, CVCs coated with green and facile laccase-manganese phosphate hybrid nanostructures [(Mn3(PO4)2·HNSs] prevented bacterial adhesion by 100%, 80%, 60%, and 58% for Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Escherichia coli, respectively. The modified CVCs inhibited planktonic bacterial growth by up to 95% under static and dynamic flow conditions. Furthermore, the prepared CVCs showed high hemocompatibility, appropriate mechanical properties, and long-term antibacterial performance, meeting the essential requirements of catheterization. The modified catheter offered superior detectability in magnetic resonance imaging (MRI) and computed tomography (CT) scans, a valuable advancement for ongoing patient monitoring. Moreover, in vivo assessment using the mouse catheterization model revealed no inflammatory response associated with the implanted CVCs. Therefore, the prepared laccase@ Mn3(PO4)2·HNSs could be a promising strategy for developing safe and effective antibacterial coatings to combat infections associated with biomedical devices.
