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Updated: May 27, 2025
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A New Ex Vivo Model for the Evaluation of Endoscopic Submucosal Injection Material Performance
Published on: October 19, 2018
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Novel submucosal injection material comprising fully synthetic and self-assembling peptide solution in endoscopic
Kengo Kasuga1, Keigo Sato1, Ko Nakata1
1Department of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, Gunma, Japan.
Endoscopy International Open
|February 17, 2025
Summary
PuraLift, a new injection solution for endoscopic submucosal dissection (ESD), demonstrated safety and feasibility in a pilot study. It effectively created submucosal cushions for resecting early gastrointestinal tumors without adverse events.
Area of Science:
- Gastroenterology
- Endoscopic Surgery
- Oncology
Background:
- Endoscopic submucosal dissection (ESD) necessitates effective submucosal injection solutions for safe tumor resection.
- Existing solutions may have limitations in maintaining submucosal cushion duration and stability.
Purpose of the Study:
- To evaluate the safety and feasibility of PuraLift, a novel injectable material, as a submucosal cushion agent during ESD for early-stage gastrointestinal neoplasms.
- To compare the efficacy of PuraLift with saline in terms of submucosal lifting maintenance.
Main Methods:
- A prospective, single-arm, single-center pilot study involving 11 patients with gastric or colorectal neoplasms.
- Patients underwent ESD using PuraLift for submucosal injection.
- Post-procedure assessment included 4-week outpatient follow-up for adverse events and operator/assistant questionnaires.
Main Results:
- All 11 patients completed the study without intraprocedural or postoperative adverse events (bleeding, perforation).
- PuraLift provided long-lasting submucosal lifting, comparable to or better than saline.
- En bloc and R0 resections were achieved in all cases, with a median specimen size of 40 mm.
Conclusions:
- PuraLift is a safe and feasible novel injectable material for creating submucosal cushions in ESD.
- The use of PuraLift in ESD for early gastrointestinal tumors shows promising results, potentially enhancing procedural safety and efficacy.
