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Clipping spline: interactive, dynamic 4D volume clipping and analysis based on thin plate spline.
1Department of Biomedical Engineering, Stevens Institute of Technology, Hoboken, NJ 07030, USA.
Biomedical Optics Express
|February 17, 2025
Summary
We developed a novel clipping spline method for dynamic 4D visualization of volumetric biomedical images. This open-source tool enhances the analysis of embryonic mouse heart development using optical coherence tomography data.
Area of Science:
- Biomedical Imaging
- Computational Biology
- Developmental Biology
Background:
- Advancements in 3D and 4D biomedical imaging necessitate improved visualization techniques.
- Traditional volume clipping methods struggle with dynamic, non-planar, and real-time interactive cutaway views.
Purpose of the Study:
- To introduce a novel, open-source volume clipping method for enhanced 4D visualization and analysis of biomedical data.
- To enable real-time, adjustable, and dynamic cutaway views for complex volumetric datasets.
Main Methods:
- Developed a 'clipping spline' using thin plate splines (TPS) to generate dynamic, non-planar cutaway views.
- Implemented an algorithm for automatic interpolation of control points for 4D volume clipping.
- Applied the method to optical coherence tomography (OCT) data of embryonic mouse heart development.
Main Results:
- The clipping spline provides smooth, adjustable, and real-time interactive 4D cutaway views.
- Revealed previously unseen dynamics of embryonic mouse heart development.
- Demonstrated TPS-based tracking of embryonic myocardium over heartbeat and developmental timescales.
Conclusions:
- The clipping spline offers a powerful tool for volumetric biomedical image visualization and analysis.
- This method is particularly beneficial for optical coherence tomography (OCT) data and the study of embryonic development.
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