Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Exercise capacity in subjects with high oxygen affinity.

E Länsimies, S Hyödynmaa, R Lahtinen

    Clinical Physiology (Oxford, England)
    |January 1, 1985
    PubMed
    Summary

    Patients with high hemoglobin oxygen affinity (Hb-Linköping variant) showed similar exercise tolerance but altered oxygen dissociation during exercise. Further studies are needed to understand potential long-term metabolic effects.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Ultra-low-dose CBCT: new cornerstone of paranasal sinus imaging.

    Rhinology·2023
    Same author

    Diagnostic Accuracy of Symptoms, Endoscopy, and Imaging Signs of Chronic Rhinosinusitis Without Nasal Polyps Compared to Allergic Rhinitis.

    American journal of rhinology & allergy·2018
    Same author

    A prospective, randomized clinical study comparing drug eluting stent therapy and intranasal corticoid steroid therapy in the treatment of patients with chronic rhinosinusitis.

    Rhinology·2017
    Same author

    Low lymphatic vessel density associates with chronic rhinosinusitis with nasal polyps.

    Rhinology·2017
    Same author

    Correlation between apparent diffusion coefficient value on diffusion-weighted MR imaging and Gleason score in prostate cancer.

    Diagnostic and interventional imaging·2016
    Same author

    Effect of the Choice of Primary Chemotherapy on the Cumulative Length of Stay in Hospital for Multiple Myeloma.

    Leukemia & lymphoma·2016

    Area of Science:

    • Physiology
    • Hematology

    Background:

    • A novel hemoglobin variant, Hb-Linköping, presents with high oxygen affinity.
    • Understanding its physiological impact during exercise is crucial.

    Purpose of the Study:

    • To evaluate exercise capacity and hemodynamic responses in individuals with Hb-Linköping.
    • To investigate the oxygen-hemoglobin dissociation characteristics during exercise.

    Main Methods:

    • Ten patients with Hb-Linköping and ten controls underwent maximal bicycle ergometer testing.
    • Measurements included exercise capacity, cardiac parameters, and hemoglobin dissociation curve analysis.

    Main Results:

    • Exercise capacity and cardiac tolerance were comparable between patients and controls.

    Related Experiment Videos

  • Hemoglobin dissociation curve showed a leftward shift at rest and a reduced rightward shift post-exercise in patients.
  • Lactate accumulation was similar, but hydrogen ion production was higher in patients during exercise.

    • Conclusions:

    • Despite high hemoglobin oxygen affinity, patients exhibit similar acute exercise tolerance and cardiovascular load.
    • Altered hydrogen ion production suggests potential metabolic adaptations requiring further investigation.
    • Long-term follow-up is recommended to assess potential effects of relative hypoxia adaptation.