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Nonsurgical Rhinoplasty: Histopathological Effects of Dermal Fillers on Nasal Cartilage in a Rabbit Model.
İbrahim Ömer Gürlek1, Filiz Gülüstan1, Burak Kaan İnan1
1Department of Otorhinolaryngology & Head and Neck Surgery, Bakırköy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Türkiye.
Facial Plastic Surgery : FPS
|February 18, 2025
Summary
Nonsurgical rhinoplasty using hyaluronic acid fillers caused cartilage changes in rabbits, including cell loss and giant cells, but not thickness reduction. Further research is needed for these aesthetic treatments.
Area of Science:
- Plastic Surgery
- Dermatology
- Histopathology
Background:
- Nonsurgical rhinoplasty, utilizing hyaluronic acid (HA) fillers, is a popular aesthetic procedure.
- Limited histopathological data exist on the effects of HA fillers on nasal cartilage.
Purpose of the Study:
- To histopathologically evaluate the effects of two HA-containing dermal fillers (VYC-20L and VYC-25L) on rabbit nasal cartilage.
Main Methods:
- Sixteen rabbits were divided into two groups, receiving either VYC-20L or VYC-25L in one lateral nasal cartilage and saline in the other (control).
- After 90 days, cartilage samples were analyzed for thickness, chondrocyte nucleus loss, inflammation, fibrosis, giant cells, abscess, and necrosis.
Main Results:
- Significant differences were observed in chondrocyte nucleus loss, fibrosis, and giant cell presence between filler-injected and control cartilages.
- No significant difference in cartilage thickness was noted.
- Giant cells were present in all samples injected with VYC-20L and VYC-25L.
Conclusions:
- HA-containing fillers VYC-20L and VYC-25L induce histopathological changes in nasal cartilage, including chondrocyte alterations and giant cell formation.
- These fillers did not affect cartilage thickness in the rabbit model.
- Further investigation with larger sample sizes and varied fillers is recommended.
