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Evaluation of Pyrones in Bioorthogonal Reactions: Correlation between Structure, Reactivity, and Bioorthogonality.

Wei Huang1, Kangqiao Wen1, Paul F Muschitiello1

  • 1Department of Chemistry, Stony Brook University, Stony Brook, New York 11790, United States.

The Journal of Organic Chemistry
|February 19, 2025
PubMed
Summary

Alpha-pyrones show promise as dienes in bioorthogonal reactions, with electron-withdrawing groups enhancing reactivity toward bicyclononyne (BCN). Substituent positions significantly influence reactivity, offering new avenues for chemical biology applications.

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