Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

597
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
597

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acute kidney injury is associated with decreased platelet function in domestic cats.

Journal of veterinary internal medicine·2026
Same author

Evaluation of point-of-care versus laboratory antiglobulin-enhanced major crossmatch testing in cats.

The Journal of small animal practice·2026
Same author

Analgesic and anti-inflammatory effects of lidocaine in dogs receiving fentanyl and undergoing thoracolumbar hemilaminectomy for intervertebral disc extrusion.

Veterinary anaesthesia and analgesia·2026
Same author

Effects of fixation and demineralization on immunohistochemical assessment of canine bone marrow.

Veterinary pathology·2026
Same author

Comparison of the Calibrated Automated Thrombogram Using Standard and Low Plasma Volumes in Dogs.

Veterinary clinical pathology·2026
Same author

Evaluation of a Deep Active Learning Model for the Segmentation of Canine Thoracic Radiographs.

Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·2025

Related Experiment Video

Updated: May 27, 2025

Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury
08:39

Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury

Published on: September 7, 2018

9.0K

Monitoring of Rivaroxaban Therapy in Hypercoagulable Dogs.

Erin M Phillips1, Shauna L Blois1, Anthony C G Abrams-Ogg1

  • 1Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.

Journal of Veterinary Internal Medicine
|February 19, 2025
PubMed
Summary

Prothrombin time (PT) and thrombin generation (TG) correlate with the rivaroxaban-specific anti-Xa assay (raXa) in dogs. PT offers a practical method for monitoring rivaroxaban therapy in canine patients.

Keywords:
anti‐Xa assayprothrombin time (PT)thrombin generation

More Related Videos

Multi-exon Skipping Using Cocktail Antisense Oligonucleotides in the Canine X-linked Muscular Dystrophy
10:30

Multi-exon Skipping Using Cocktail Antisense Oligonucleotides in the Canine X-linked Muscular Dystrophy

Published on: May 24, 2016

18.6K
Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models
04:40

Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models

Published on: January 5, 2024

2.1K

Related Experiment Videos

Last Updated: May 27, 2025

Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury
08:39

Ferric Chloride-induced Canine Carotid Artery Thrombosis: A Large Animal Model of Vascular Injury

Published on: September 7, 2018

9.0K
Multi-exon Skipping Using Cocktail Antisense Oligonucleotides in the Canine X-linked Muscular Dystrophy
10:30

Multi-exon Skipping Using Cocktail Antisense Oligonucleotides in the Canine X-linked Muscular Dystrophy

Published on: May 24, 2016

18.6K
Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models
04:40

Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models

Published on: January 5, 2024

2.1K

Area of Science:

  • Veterinary Medicine
  • Pharmacology
  • Hematology

Background:

  • Monitoring rivaroxaban efficacy in veterinary patients is crucial for therapeutic management.
  • The rivaroxaban-specific anti-Xa assay (raXa) is a validated method for rivaroxaban monitoring.
  • Alternative hemostatic tests could enhance the accessibility and timeliness of rivaroxaban monitoring.

Purpose of the Study:

  • To compare the results of the rivaroxaban-specific anti-Xa assay (raXa) with various other hemostatic tests.
  • To evaluate the utility of prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, thromboelastography (TEG), and thrombin generation (TG) for monitoring rivaroxaban in hypercoagulable dogs.

Main Methods:

  • A prospective clinical trial involving twelve client-owned dogs with hypercoagulability or thromboembolic disease treated with rivaroxaban.
  • Blood samples were collected at baseline, 1 week, and 1-3 months post-rivaroxaban initiation.
  • Hemostatic tests, including raXa, PT, aPTT, fibrinogen, TEG, and TG, were performed 3 hours after rivaroxaban dosing.

Main Results:

  • Significant linear correlations were observed between raXa and PT (r²=0.74), and multiple thrombin generation parameters (ETP, lag time, peak, ttpeak) (r² values ranging from 0.83 to 0.87).
  • A weak linear relationship was found between raXa and the TEG reaction time (R) (r²=0.49).
  • No significant relationships were detected between raXa and aPTT, fibrinogen, or other TEG variables.

Conclusions:

  • Prothrombin time (PT) and thrombin generation (TG) demonstrate a correlation with the rivaroxaban-specific anti-Xa assay (raXa).
  • PT, when performed at a reference laboratory, presents a convenient and accessible method for monitoring rivaroxaban therapy in dogs.
  • These findings support the potential use of PT as a practical alternative for rivaroxaban monitoring in veterinary patients.