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Topical Trametinib for Agminated Spitz Nevi Harboring HRAS Mutation
Lauren Parsons1, Alice Chen2, Brooke Bertus3
1West Virginia University School of Medicine, Morgantown, West Virginia, USA.
Pediatric Dermatology
|February 19, 2025
Summary
Agminated Spitz nevi, a challenging condition, were effectively treated in a pediatric patient using topical trametinib cream. This targeted therapy shows promise for HRAS-mutated nevi, offering a non-surgical option.
Area of Science:
- Dermatology
- Genetics
- Pediatric Oncology
Background:
- Agminated Spitz nevi present treatment challenges, particularly in cosmetically sensitive facial areas, due to potential disfigurement.
- The genetic underpinnings of some Spitz nevi, including those arising from nevus spilus, are increasingly being identified.
