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Related Concept Videos

Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Asthma-IV: Nursing Management01:30

Asthma-IV: Nursing Management

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The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-I: Introduction01:29

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
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Update in paediatric asthma.

Andrew Bush1

  • 1National Heart and Lung Institute, Imperial College, and Imperial Centre for Paediatrics and Child Health, Consultant Paediatric Chest Physician, Royal Brompton Hospital, London, UK.

Current Opinion in Pulmonary Medicine
|February 20, 2025
PubMed
Summary
This summary is machine-generated.

New biologics show promise for severe paediatric asthma and preschool wheeze. Personalized, biomarker-driven treatments are advancing, focusing on airway remodeling and environmental factors for better asthma management.

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Area of Science:

  • Pediatric respiratory medicine
  • Immunology
  • Environmental health

Background:

  • Paediatric asthma management is evolving with new biological therapies and a deeper understanding of preschool wheeze.
  • Current research highlights advancements in treating severe asthma and early childhood respiratory symptoms.

Purpose of the Study:

  • To review recent developments in paediatric asthma and preschool wheeze.
  • To discuss the role of biologics, biomarkers, and environmental factors in respiratory health.

Main Methods:

  • Review of current scientific literature on paediatric asthma and wheeze.
  • Analysis of emerging treatment strategies, including biologics and personalized medicine approaches.

Main Results:

  • Biologics like mepolizumab, dupilumab, and Tezepelumab show efficacy in children with Type 2 and Type 2 low asthma phenotypes.
  • Airway remodeling and infection are key in preschool wheeze pathophysiology; treatment is shifting towards biomarker-driven therapies.
  • Environmental factors, climate change, and inhaler emissions are critical considerations in pediatric respiratory care.

Conclusions:

  • Personalized medicine and biomarker-guided treatments are crucial for all ages, requiring a move towards assessing cell function over counts.
  • Airway structural changes, not just inflammation, may be the primary driver of preschool wheeze progression to school-age asthma.