[Congenital ichthyosiforme erythroderma, pregnancy under aromatic retinoid treatment]

Long-term treatment with aromatic retinoid (Tigason) gives excellent results in lamellar ichthyosis (non-bullous congenital ichthyosiform erythroderma), which is demonstrated in a young woman who was treated with Tigason for about 4 years. She was under treatment when a pregnancy was beginning. Although 2 days after birth the child showed pronounced icterus, except for elevations of SGOT and SGPT at present, the 5-month-old boy has no symptoms of internal or skin disease. It is known that aromatic retinoid has embryotoxic and teratogenic effects and should not to be given to women of childbearing potential without contraception. Pregnancy should not be allowed until 2 years after withdrawal of therapy because retinoid remains in the body for a long time.