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Updated: May 27, 2025
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Generation of Cationic Nanoliposomes for the Efficient Delivery of In Vitro Transcribed Messenger RNA
Published on: February 1, 2019
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Developing mRNA Nanomedicines with Advanced Targeting Functions.
Ji Wang1,2, Lijun Cai2, Ning Li2
1Department of Radiology, Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing, 210008, People's Republic of China.
Nano-Micro Letters
|February 20, 2025
Summary
Targeted messenger RNA (mRNA) nanomedicines offer precise disease treatment by delivering mRNA to specific sites. This review explores targeting strategies, biological barriers, and clinical translation of these advanced therapies.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Molecular Medicine
Background:
- Messenger RNA (mRNA) nanomedicines are emerging as a powerful platform for disease treatment.
- Targeted delivery of mRNA nanomedicines enhances therapeutic efficiency and minimizes off-target side effects.
- Recent advancements focus on developing sophisticated strategies for precise organ and tissue targeting.
Purpose of the Study:
- To provide a comprehensive review of the latest research on mRNA nanomedicines with targeting functions.
- To elucidate the mechanisms of passive, endogenous, and active targeting for mRNA delivery.
- To discuss the biological barriers, organ-targeting strategies, and clinical translation challenges of mRNA nanomedicines.
Main Methods:
- Detailed description of mRNA and its various carriers.
- Outline of passive, endogenous, and active targeting mechanisms.
- Analysis of biological barriers encountered during in vivo delivery.
- Summary of organ-targeting strategies for mRNA-based therapies.
Main Results:
- Identification of key targeting mechanisms and their associated biological barriers.
- Overview of diverse strategies employed for organ-specific mRNA delivery.
- Discussion on the current state and future prospects of mRNA nanomedicines in clinical settings.
Conclusions:
- Targeted mRNA nanomedicines represent a significant advancement in precision medicine.
- Overcoming biological barriers and optimizing targeting strategies are crucial for clinical translation.
- Further research in mRNA targeting technology holds immense potential for future therapeutic applications.
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