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2-Brain Regulation for Improved Neuroprotection during Early Development (2-BRAINED): a translational hyperscanning
Lucia Billeci1, Valentina Riva2, Elena Capelli3
1Clinical Physiology Institute, National Research Council of Italy (IFC-CNR), Pisa, Italy.
Insights
Early video-feedback interventions improve very preterm infant development and parental well-being. EEG hyperscanning reveals enhanced brain-to-brain co-regulation in dyads receiving this intervention, offering insights into its mechanisms.
Area of Science:
- Neuroscience
- Developmental Psychology
- Pediatrics
Background:
- Very preterm (VPT) birth poses risks to infant development and parental well-being due to NICU stressors.
- Early video-feedback (VF) interventions show promise in supporting VPT infants and their parents.
- Electroencephalography (EEG) hyperscanning enables studying brain-to-brain co-regulation during parent-infant interactions.
Purpose of the Study:
- Compare brain-to-brain co-regulation indices between full-term (FT) and VPT infant dyads.
- Investigate the impact of an early post-discharge VF intervention on VPT dyads' brain-to-brain co-regulation.
Main Methods:
- Enrollment of FT and VPT dyads at birth, with VPT infants randomized to VF intervention or care as usual.
- Assessment of mother-infant interaction, maternal mental state, parenting stress, bonding, and infant temperament.
- EEG hyperscanning at 9 months corrected age to measure brain-to-brain co-regulation using phase-locking value (PLV).
Main Results:
- (Study is ongoing, results not yet available)
Conclusions:
- (Study is ongoing, conclusions not yet available)
Introduction:
Very preterm (VPT) birth is a major risk condition for child development and parental wellbeing, mainly due to multiple sources of stress (e.g., separation and pain exposure) during the neonatal intensive care unit (NICU) stay. Early video-feedback (VF) interventions proved effective in promoting VOT infants' development and parental wellbeing. Electroencephalography (EEG) hyperscanning allows the assessment of brain-to-brain co-regulation during live interaction between infants and parents, offering promising insights into the mechanisms behind the interactive benefits of early VF interventions.
Goals:
This study aimed to compare indices of brain-to-brain co-regulation between dyads of full-term (FT) and VPT infants interacting with their mothers and investigate the effect of an early post-discharge VF intervention on the brain-to-brain co-regulation indices of VPT dyads.
Methods And Analysis:
VPT and FT dyads will be enrolled at birth, and the former will be randomly allocated to one of two arms: VF intervention or care as usual. Short-term effectiveness will be assessed through ratings of mother-infant interaction videotaped before and after the VF intervention or care as usual. Mothers of VPT and FT infants will report on their mental state, parenting stress and bonding, and infant temperament and sensory profile at 3 and 6 months (corrected age, CA). At 9 months CA, all dyads will participate in a lab-based EEG-hyperscanning paradigm to assess brain-to-brain co-regulation through phase-locking value (PLV) and other explorative indices.
Ethics And Dissemination:
This study was funded by the Italian Ministry of Health and received approval by the Ethics Committee of Pavia (Italy) and participating hospitals. Research findings will be reported in scientific publications, presented at international conferences, and disseminated to the general public.
Study Registration Number:
GR-2021-12375213 (Italian Ministry of Health registry).
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