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NBS-mediated C(sp3)-H amidation of N,N-dimethylamides with N-acyloxyamides
Shuangqing Li1, Xianru Xu1, Guojuan Yin1
1College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China. xyz@wzu.edu.cn.
Abstract:
Presented herein is the NBS-mediated amidation of the C(sp3)-H bond adjacent to the nitrogen atom of N,N-dimethylamide using N-acyloxyamide as the amide source, leading to a diverse array of methylenebisamides. The transformation features mild conditions, excellent functional group tolerance, and high efficiency. The practicality of the methodology was shown by gram-scale synthesis and efficient product derivatization. Preliminary study indicated that the amidation might be realized by cross coupling between nitrogen and carbon radicals.
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