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Updated: May 26, 2025

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Palladium-Catalyzed Site-Selective C-H Sulfonylation via Aryl Thianthrenium Salts to Access Diarylsulfones
Chunjie Ni1, Jin-Ping Liu2, Xiao-Xu Zhang2
1School of Pharmacy, Yancheng Teachers University, Yancheng, Jiangsu 224007, P. R. China.
Abstract:
We presented a highly efficient palladium-catalyzed site-selective C-H sulfonylation reaction via aryl thianthrenium salts. By utilizing readily available and cost-effective arenes along with sodium sulfinates, we achieved the C(sp2)-S cross-coupling with high efficiency, establishing a dependable method for synthesizing diarylsulfones with satisfactory yields. This method exhibits excellent tolerance toward functional groups, scalability, and the synthesis or late-stage functionalization of bioactive molecules, making it a valuable sulfonylation tool for drug modifications.
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