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Updated: May 26, 2025

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Merging Enantioselective Lewis Base Organocatalysis and Gold(I) Catalysis: A One-Pot Access to Chiral-Fused
Rémi Pereira1, Pierre Locquet2, Aurélien Blanc2
1Université de Reims Champagne-Ardenne, CNRS, Institut de Chimie Moléculaire de Reims, UMR 7312, Reims 51097, France.
Abstract:
Reported herein is a route to functionalized chiral heteroaromatic polycyclic compounds leveraging two unfriendly catalytic cycles in a one-pot sequential process. α-Heteroaromatic-γ-butyrolactones were engaged in a highly regio-, diastereo-, and enantio-selective Lewis base asymmetric allylic alkylation (AAA) with alkyne-functionalized Morita-Baylis-Hillman (MBH) carbonates. Gratefully, due to the low Lewis base catalyst loading, subsequent gold-catalyzed Friedel-Crafts type cyclization, entailing the formation of fused polycyclic compounds, proceeded efficiently, affording structurally complex, highly enantioenriched products.
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