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Updated: May 26, 2025

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Two undescribed benzofuran derivatives from chaetomium elatum
Chen-Yi Yan1,2,3, Feng Ju4, Yu-Hui Chen5
1State Key Laboratory of Southwestern Chinese Medicine Resource, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
None:
Two undescribed benzofuran derivatives (1-2) were isolated from Chaetomium elatum using silica gel, Sephadex LH-20 column chromatography, and preparative high-performance liquid chromatography (HPLC). The structures of compound 1-2 were characterised by HRESIMS, NMR, HMBC, NOESY spectral analyses, and ECD calculations. Compounds 1-2 demonstrated the ability to mitigate the inflammatory response triggered by lipopolysaccharide (LPS) in RAW264.7 macrophages, as evidenced by RT-PCR assay results showing suppression of key inflammatory factors at the concentration of 30 μM. These findings suggest that 1-2 possess promising anti-inflammatory properties.
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