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Updated: May 5, 2026

Establishing Fungal Entomopathogens as Endophytes: Towards Endophytic Biological Control
Published on: April 11, 2013
Two new tetralones from the endophytic fungus Annulohypoxylon stygium A888
Zhi-Shen Shao1,2, Yu-Chan Chen2, Wei-Peng Ma2
1School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Abstract:
Two new tetralones, annulohyporins A (1) and B (2), along with thirteen known compounds (3-15), were isolated from the ethyl acetate extract of solid fermentation of the endophytic fungus Annulohypoxylon stygium A888, which was isolated from the medicinal plant Aquilaria sinensis. The structures of annulohyporins A and B were established by detailed analyses of ultraviolet-visible spectroscopy (UV), infrared spectroscopy (IR), mass spectrometry (MS), electronic circular dichroism (ECD) calculations and nuclear magnetic resonance (NMR). Bioactivity assay showed that compounds 3 and 4 had significant α-glucosidase inhibitory activities with IC50 values of 64.00 and 32.90 µM, respectively.
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