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Related Experiment Video

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A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
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Brain white matter damage biomarkers.

Fardin Nabizadeh1

  • 1School of Medicine, Iran University of Medical Sciences, and Alzheimer's Disease Institute, Tehran, Iran.

Advances in Clinical Chemistry
|February 23, 2025
PubMed
Summary

Fluid biomarkers like myelin basic protein (MBP) and neurofilament light chain (NFL) are crucial for assessing white matter (WM) damage in the central nervous system (CNS). These biomarkers aid in diagnosis, monitoring, and treatment of neurological conditions affecting WM integrity.

Keywords:
BiomarkerCSFSynapseWhite matter

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Clinical Neurology

Background:

  • White matter (WM) is vital for neural signal transmission and cognitive functions.
  • Damage to WM, seen in conditions like MS and stroke, leads to neurological deficits.
  • Assessing WM integrity is crucial for understanding and managing neurological diseases.

Purpose of the Study:

  • To discuss the clinical significance of fluid biomarkers in evaluating central nervous system (CNS) white matter damage.
  • To explore the biological basis and pathological changes in WM relevant to neurological conditions.
  • To detail the detection and quantification of WM alterations using fluid biomarkers.

Main Methods:

  • Review of existing literature on white matter pathology and fluid biomarkers.
  • Examination of specific biomarkers such as Myelin Basic Protein (MBP) and Neurofilament light chain (NFL).
  • Analysis of how these biomarkers aid in diagnosis, disease monitoring, and therapeutic guidance.

Main Results:

  • Fluid biomarkers offer a non-invasive method to detect and quantify WM damage.
  • Biomarkers like MBP and NFL show potential in assessing the extent and progression of WM pathology.
  • These markers can differentiate between various neurological conditions affecting white matter.

Conclusions:

  • Fluid biomarkers are essential tools for clinical assessment of WM damage in the CNS.
  • Utilizing biomarkers enhances diagnostic accuracy, disease progression monitoring, and treatment strategies.
  • This approach provides critical insights for preventing cognitive and physical disabilities associated with WM damage.