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Related Experiment Video

Updated: May 26, 2025

Microfluidic-based Synthesis of Covalent Organic Frameworks COFs: A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface
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Radioactive Diselenide Bonded Covalent Organic Framework.

Liang Zhang1,2, Shuo Wang1, Qi-Chao Yang1

  • 1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Center for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, 430079, China.

Advanced Materials (Deerfield Beach, Fla.)
|February 24, 2025
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel radioactive covalent organic framework (COF) using diselenide bonds. This material releases drugs upon irradiation, enhancing radiotherapy by promoting PANoptosis and improving the tumor microenvironment.

Keywords:
PANoptosiscovalent organic frameworks (COFs)diselenide bondsradiotherapy

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • Covalent organic frameworks (COFs) show promise for biomedical applications.
  • The stability and drug-release capabilities of COFs are crucial for therapeutic efficacy.
  • Designing responsive biomaterials requires innovative chemical strategies.

Purpose of the Study:

  • To synthesize a novel radioactive COF with labile diselenide bonds for controlled drug release.
  • To investigate the therapeutic potential of this COF in cancer treatment.
  • To explore the application of clip-off chemistry in developing advanced biomaterials.

Main Methods:

  • Synthesis of a diselenide-bonded COF (PorSe-CuPt) incorporating Cu and Pt ion porphyrin units.
  • Incorporation of the drug molecule CBL0137 into the COF pores.
  • Irradiation-induced cleavage of diselenide bonds for drug release.
  • Evaluation of X-ray absorption, oxygen enrichment, and PANoptosis induction.

Main Results:

  • The synthesized PorSe-CuPt COF effectively released the carried drug molecule upon irradiation.
  • Pt²⁺ promoted X-ray absorption, while Cu²⁺ enriched oxygen, enhancing therapeutic effects.
  • Robust PANoptosis was achieved, alongside an improved immunosuppressive tumor microenvironment.
  • The study demonstrated enhanced radiotherapy effectiveness.

Conclusions:

  • The integration of labile diselenide bonds into COFs enables clip-off chemistry for controlled drug delivery.
  • This approach leads to highly responsive and compatible biomaterials for biomedical applications.
  • The developed radioactive COF shows significant potential for improving cancer radiotherapy outcomes.