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Assessing the Validity of Computerized Algorithms for Determining Pulse Wave Velocity: A Clinical Study.

Amira Tairi1, Hasan Obeid2, Saliha Addour2

  • 1Division of Nephrology, Department of Medicine, CHU de Québec-Université Laval Research Center, Faculty of Medicine, Université Laval, Québec City, QC, Canada.

Pulse (Basel, Switzerland)
|February 24, 2025
PubMed
Summary
This summary is machine-generated.

The study found that the second-derivative and intersecting tangents algorithms for calculating pulse wave velocity (PWV) yield negligible differences in results. This suggests no need to adjust PWV measurements based on the algorithm used for pulse transit time determination.

Keywords:
Arterial stiffnessComputerized algorithmsPulse wave velocityWave foot detection

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Area of Science:

  • Cardiovascular Physiology
  • Biomedical Engineering
  • Medical Diagnostics

Background:

  • Aortic stiffness, measured by carotid-femoral pulse wave velocity (PWV), is a key cardiovascular risk factor.
  • Accurate PWV measurement relies on precise identification of the pulse waveform foot.
  • Existing methods, such as second-derivative and intersecting tangents algorithms, can produce differing PWV results.

Purpose of the Study:

  • To compare pulse transit time (PTT) and PWV calculated by second-derivative and intersecting tangents algorithms.
  • To evaluate differences when both algorithms process identical input signals.

Main Methods:

  • Analyzed 3,770 pairs of filtered pulse waves from 113 subjects using MATLAB.
  • Calculated PTT and PWV with second-derivative (PTTMat-2nd, PWVMat-2nd) and intersecting tangents (PTTMat-IT, PWVMat-IT) algorithms.
  • Compared results with Complior (PWVComp-2nd) and SphygmoCor (PWVSphyg-IT) systems.

Main Results:

  • Mean PTT values were nearly identical: 54.55 ± 18.55 ms (2nd derivative) vs. 54.61 ± 18.61 ms (intersecting tangents).
  • Mean PWV values showed minimal differences: 0.01 ± 0.32 m/s between MATLAB algorithms (PWVMat-2nd vs. PWVMat-IT).
  • Differences between device-specific algorithms were also small: 0.11 ± 0.66 m/s (PWVComp-2nd vs. PWVSphyg-IT).

Conclusions:

  • The differences in PWV calculated by the second-derivative and intersecting tangents algorithms are negligible.
  • No adjustment is needed for PWV measurements based on the algorithm used for PTT determination.
  • This finding simplifies the interpretation of PWV measurements across different analytical approaches.