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Related Experiment Video

Updated: May 26, 2025

Physiological Experimentation with the Crayfish Hindgut: A Student Laboratory Exercise

Physiological Experimentation with the Crayfish Hindgut: A Student Laboratory Exercise

Published on: January 18, 2011

The long road to Ithaca: a physiologist's journey.

Sadis Matalon¹

¹Division of Molecular and Translational Biomedicine, Department of Anesthesiology and Perioperative Medicine, Heersink School of Medicine UAB | The University of Alabama at Birmingham, Birmingham, Alabama, United States.

American Journal of Physiology. Cell Physiology

|February 24, 2025

Summary

This lecture explores how free heme contributes to acute lung injury. Researchers are developing recombinant human hemopexin as a potential countermeasure to protect the blood gas barrier.

Keywords:

chlorine heme hemopexin lung injury proteomics

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Area of Science:

Physiology
Pathophysiology
Lung Injury

Background:

Walter B. Cannon pioneered "fight or flight" and Homeostasis.
The lecture title is inspired by C. P. Cavafy's poem "Ithaca."
The speaker reflects on a career in respiration physiology and scientific contribution.

Observation:

Oxidant gases and pathogens damage the blood gas barrier.
This damage leads to acute and chronic lung injury.
Free heme is identified as a key mediator in acute lung injury.

Findings:

Current studies implicate free heme in acute lung injury.
Research focuses on understanding the mechanisms of blood gas barrier damage.
Efforts are underway to develop countermeasures for lung injury.

Implications:

Understanding heme's role can lead to new treatments for lung injury.
Developing hemopexin offers a potential therapeutic strategy.
This work contributes to the broader field of respiratory medicine and critical care.