Allergen immunotherapy-induced anaphylaxis: Data from the European Anaphylaxis Registry

Area of Science:

• Allergy and Immunology
• Clinical Medicine
• Pharmacovigilance

Background:

• Limited data exist on anaphylaxis induced by allergen immunotherapy (AIT).
• This study utilizes data from the European Anaphylaxis Registry to investigate AIT-induced anaphylaxis.

Purpose of the Study:

• To analyze the characteristics, symptoms, severity, and emergency management of AIT-induced anaphylactic reactions.
• To compare these factors across different age groups and allergenic sources.

Main Methods:

• Data collected from 54 European allergy centers (2007-2023).
• Analysis of anaphylactic reactions involving at least two organ systems.
• Statistical analysis using chi-squared and Fisher's exact tests.

Main Results:

• AIT accounted for 1.1% of registry cases; 1.8% pediatric, 0.7% adult.
• Respiratory symptoms more common in children; cardiovascular/gastrointestinal in adults.
• Adrenaline underused; delayed reactions noted, particularly in children with severe reactions.

Conclusions:

• Age-specific monitoring is crucial for patient safety during AIT.
• Appropriate emergency treatment protocols need enhancement for AIT-related anaphylaxis.