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Correlation between gut microbiota and tumor immune microenvironment: A bibliometric and visualized study
Zheng-Jun Hu1, Hui-Rong Zhu2, Yong-Jie Jin1
1Department of Oncology, Shanghai Jiading District Hospital of Traditional Chinese Medicine, Shanghai 200000, China.
World Journal of Clinical Oncology
|February 25, 2025
Summary
This bibliometric analysis reveals a surge in gut microbiota and tumor immune microenvironment (TIME) research since 2019. China leads publications, while the US shows the most influence, with immunotherapy emerging as a key research focus.
Area of Science:
- Investigates the intersection of microbiology, immunology, and oncology.
- Utilizes bibliometric analysis to map the scientific landscape of gut microbiota and the tumor immune microenvironment (TIME).
Background:
- Growing evidence links gut microbiota composition to the tumor immune microenvironment (TIME).
- A systematic bibliometric study was lacking to comprehensively assess this research area.
Purpose of the Study:
- To provide a bibliometric overview of global research on gut microbiota and TIME.
- To identify leading countries, institutions, researchers, and emerging research themes in this field.
Main Methods:
- Bibliometric analysis of 491 publications from Web of Science Core Collection (2014-2024).
- Utilized CiteSpace, VOSviewer, and R for data visualization and analysis of countries, institutions, authors, and keywords.
Main Results:
- Publication numbers rapidly increased from 2019 onwards.
- China and the United States are the most prolific countries; the US exhibits the highest influence.
- Key research hotspots include 'gut microbiota,' 'tumor microenvironment,' and 'immunotherapy.'
Conclusions:
- The field of gut microbiota and TIME research has expanded significantly over the past decade.
- Future research should focus on specific gut microbes, their metabolites, and their impact on immune cells and immunotherapy efficacy.
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