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Apoptosis-inducing proteins with reduced expression in breast cancer: A review article

Mohammad Mehdi Khaleghi1, Faezeh Rouhi2, Kourosh Eslami3

  • 1Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.

Biochemistry and Biophysics Reports
|February 25, 2025
PubMed

Insights

This review explores novel protein therapies, including KAI1, Apoptin, BIF-1, and DFF-40, for breast cancer treatment, focusing on targeted apoptosis induction and improved delivery strategies for enhanced efficacy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Breast cancer presents significant global health challenges with high morbidity and mortality.
  • Traditional treatments often lack specificity and cause severe side effects.
  • There is a critical need for innovative, targeted therapies with improved safety and efficacy.

Purpose of the Study:

  • To review recent advancements in protein-based targeted therapy for breast cancer.
  • To evaluate the therapeutic potential of KAI1, Apoptin, BIF-1, and DFF-40 proteins.
  • To discuss strategies for enhancing protein delivery and overcoming treatment resistance.

Main Methods:

  • Literature review of recent studies on specific proteins and breast cancer.
  • Analysis of protein expression alterations, particularly androgenic proteins.
  • Exploration of novel drug delivery systems for protein therapeutics.

Main Results:

  • Identified KAI1, Apoptin, BIF-1, and DFF-40 as promising agents for inducing apoptosis in breast cancer cells.
  • Highlighted the importance of understanding androgenic protein expression in treatment response.
  • Discussed innovative strategies for improved protein penetration and targeted delivery.

Conclusions:

  • Protein-based targeted therapy offers a promising avenue for more effective and safer breast cancer treatment.
  • Further research into protein delivery and expression modulation is crucial for clinical translation.
  • These novel proteins represent a significant advancement in the pursuit of personalized breast cancer therapies.
Keywords:
ApoptosisBreast neoplasmsDown-regulationGene expressionProteins

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