Related Experiment Video
Updated: May 26, 2025
Perturbations of Circulating miRNAs in Irritable Bowel Syndrome Detected Using a Multiplexed High-throughput Gene Expression Platform
Published on: November 30, 2016
Multifluid Metabolomics Identifies Novel Biomarkers for Irritable Bowel Syndrome
Daniel Kirk1, Panayiotis Louca1, Ilias Attaye1,2,3
1Department of Twin Research & Genetic Epidemiology, King's College London, London SE1 7EH, UK.
This study identified 44 unique metabolite markers for irritable bowel syndrome (IBS) across serum, urine, and stool. Multi-fluid metabolomics revealed distinct metabolic signatures, offering new insights into IBS mechanisms.
Area of Science:
- Metabolomics
- Gastroenterology
- Systems Biology
Background:
- Irritable bowel syndrome (IBS) affects 10% of the global population, with poorly understood underlying mechanisms.
- Identifying reliable biomarkers is crucial for understanding and managing IBS.
Purpose of the Study:
- To identify metabolite markers associated with IBS using a multi-fluid metabolomics approach.
- To explore distinct metabolic signatures across different biofluids in a large cohort.
Main Methods:
- Analysis of serum, urine, and stool metabolites in individuals with and without IBS from the TwinsUK cohort.
- Utilized Rome III criteria for IBS ascertainment and Metabolon Inc. for metabolite profiling.
Main Results:
- Identified 44 unique metabolites associated with IBS, including lipids, amino acids, and xenobiotics.
- Androsterone sulfate and suberate showed significant associations with IBS in specific biofluids.
- Discovered 32 fluid-specific metabolites and identified over-represented metabolic pathways like androgenic signaling and dicarboxylates.
Conclusions:
- A multi-fluid metabolomics approach is valuable for IBS research.
- Distinct metabolic signatures exist across biofluids in individuals with IBS.
- Findings provide novel insights into the complex metabolic underpinnings of IBS.
More Related Videos
08:42Using Multi-fluorinated Bile Acids and In Vivo Magnetic Resonance Imaging to Measure Bile Acid Transport
Published on: November 27, 2016
07:05Fluorescence-mediated Tomography for the Detection and Quantification of Macrophage-related Murine Intestinal Inflammation
Published on: December 15, 2017
Related Concept Videos
01:17Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
01:30Irritable Bowel Syndrome III: Medical and Nursing Management
01:17Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
01:30Serum Laboratory Studies, Stool Test, Breath Test