Difluprednate for the Treatment of Postoperative Hypotony Following Complicated Retinal Detachment Surgery

This study assessed the impact of topical difluprednate on increasing intraocular pressure (IOP) in patients with hypotony following successful surgical repair of complex RD.

A retrospective, consecutive case series was conducted on patients treated with topical difluprednate for hypotony after successful complex RD repair.

Medical records of 230 patients were reviewed, and 39 eyes of 39 patients were found to develop hypotony (IOP < 8 mmHg) at least 1 month after their last surgery. Patients presented with hypotony at a mean of 41 days after their last surgery. After initiation of topical difluprednate, there was a statistically significant increase in mean IOP from the initial (5.6 mmHg) to final visit (8.6 mmHg, P = 0.032). At the last follow-up visit, one patient had progressed to phthisis bulbi.

Topical difluprednate therapy for hypotony following successful complex RD repair resulted in a statistically significant increase in IOP. [Ophthalmic Surg Lasers Imaging Retina 2025;56:266-272.].