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Hallmarks of ovarian aging
Chuqing Wu1, Dan Chen1, Michael B Stout2
1Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, Hubei, China; National Clinical Research Center for Obstetrical and Gynecological Diseases, 430030 Wuhan, Hubei, China; Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education, 430030 Wuhan, Hubei, China.
Trends in Endocrinology and Metabolism: TEM
|February 25, 2025
Summary
Ovarian aging drives female aging and related diseases. This review identifies nine key hallmarks of ovarian aging, offering potential targets for interventions to slow aging and improve health.
Area of Science:
- Reproductive biology
- Gerontology
- Molecular biology
Background:
- Ovarian aging is a critical factor in female aging and is associated with comorbidities like osteoporosis, cardiovascular disease, and cognitive decline.
- Current understanding of ovarian aging mechanisms is limited, hindering prediction and intervention strategies.
Purpose of the Study:
- To propose nine common hallmarks of ovarian aging.
- To highlight the potential for these hallmarks to serve as predictive and interventional targets.
Main Methods:
- This review synthesizes existing research on ovarian aging.
- It identifies and defines nine proposed hallmarks of ovarian aging.
Main Results:
- Nine hallmarks of ovarian aging were identified: genomic instability, telomere attrition, epigenetic alterations, impaired autophagy, cellular senescence, deregulated nutrient-sensing, mitochondrial dysfunction, oxidative stress, and chronic inflammation.
- These hallmarks represent common features of the aging process in ovaries.
Conclusions:
- Understanding the interplay between these nine hallmarks is crucial for developing strategies to attenuate ovarian aging.
- Identifying pharmaceutical targets based on these hallmarks may lead to interventions for age-related comorbidities.
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