Asiaticoside-Loaded Multifunctional Bioscaffolds for Enhanced Hyperglycemic Wound Healing

The review explores the potential of asiaticoside-loaded bioscaffolds to improve the management of hyperglycemic wounds, particularly diabetic foot ulcers (DFUs). Asiaticoside, sourced from Centella asiatica, possesses properties that address DFUs' healing challenges: insufficient angiogenesis, persistent inflammation, and delayed tissue regeneration. By incorporating asiaticoside into bioscaffold 3D designs including hydrogels, microneedle arrays, and nanofibrous meshes, therapeutic efficacy is optimized. This review examines the mechanisms of asiaticoside in wound healing (collagen production, angiogenesis modulation, inflammation reduction, and cell migration and proliferation) based on in vitro and in vivo studies. Asiaticoside also demonstrates synergistic abilities with other biomaterials, creating the possibility of more effective therapies. While preclinical research is promising, clinical trials are crucial to evaluate the efficacy and safety of asiaticoside-loaded bioscaffolds in patients with DFUs. Asiaticoside-loaded bioscaffolds are a significant development in wound healing and may aid in treating hyperglycemic wound complications. Their ability to offer individualized treatment plans has the potential to enhance the quality of life of those who suffer from diabetes. This review is based on a thorough literature search (2019-2024) across multiple databases, excluding secondary literature and non-English articles.