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Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers
Published on: March 3, 2023
MODERN METHODS OF SURGICAL TREATMENT OF DIABETIC FOOT SYNDROME
T Toleutayev1, A Dyussupov2, M Imanbaev1
11Department of Cardiovascular and Thoracic Surgery named after B.S. Bulanov, Non-Commercial Joint-Stock Company "Semey Medical University" (NCJSC «SMU»), Republic of Kazakhstan.
Revascularization interventions like angioplasty and bypass surgery show better outcomes for diabetic foot syndrome, improving wound healing and blood flow. Non-revascularization methods may be suitable for less severe cases, requiring individualized treatment plans.
Area of Science:
- Vascular Surgery
- Diabetology
- Podiatry
Background:
- Diabetic foot syndrome presents significant surgical challenges with potential complications in both early and late postoperative periods.
- Optimal surgical tactics are continuously sought to manage this complex condition effectively.
Purpose of the Study:
- To evaluate and compare the outcomes of surgical treatments using revascularization versus non-revascularization methods in patients diagnosed with diabetic foot syndrome.
Main Methods:
- A non-randomized controlled clinical trial was conducted involving 93 patients with lower limb arterial disease and diabetes mellitus.
- Patients were divided into two groups: 45 underwent revascularization (angioplasty, bypass) and 48 underwent non-revascularization (lumbar sympathectomy, osteotrepanation).
Main Results:
- Revascularization interventions, particularly angioplasty and bypass, demonstrated superior wound healing and management of lower limb ischemia.
- While some complications occurred with revascularization (e.g., angioplasty, bypass), non-revascularization methods reported no complications.
- Despite complications, revascularization showed overall better clinical results in managing diabetic foot syndrome.
Conclusions:
- Revascularization therapies (angioplasty, bypass) are more effective than non-revascularization techniques for diabetic foot syndrome, improving blood flow and accelerating wound healing.
- Treatment choice should be individualized, considering vascular damage, comorbidities, and patient characteristics.
- Non-revascularization methods may be effective and less invasive for less severe circulatory issues.
