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The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
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IMPROVEMENT OF COGNITIVE FUNCTION IN WISTAR RATS UNDER CHRONIC STRESS CONDITIONS WITH MELATONIN.

M Ramazanov1, D Bogaevskaya2, D Sobolev1

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High doses of melatonin significantly improved cognitive performance in rats under chronic stress. Low doses of melatonin and choline alphoscerate did not offer similar benefits, highlighting melatonin

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Stress Research

Background:

  • Chronic stress negatively impacts cognitive functions like memory and attention.
  • Melatonin and choline alphoscerate are investigated for their potential neuroprotective effects.
  • Wistar rats were used as a model to study stress-induced cognitive impairment.

Purpose of the Study:

  • To evaluate the efficacy of different melatonin dosages and choline alphoscerate on cognitive performance in rats subjected to chronic stress.
  • To compare the effects of melatonin and choline alphoscerate against a control group under stress.
  • To analyze changes in cortisol and melatonin levels in response to stress and treatment.

Main Methods:

  • Wistar rats were exposed to chronic stress using the Porsolt's forced swim test.
  • Rats were administered varying dosages of melatonin or choline alphoscerate.
  • Cognitive performance was assessed by measuring maze completion time.
  • Blood samples were collected to monitor cortisol and melatonin levels.

Main Results:

  • High-dose melatonin significantly improved maze completion times compared to the control group.
  • Low-dose melatonin and choline alphoscerate showed no significant cognitive improvement.
  • Cortisol levels increased across all groups, indicating a successful stress induction.

Conclusions:

  • High-dose melatonin demonstrates significant potential in mitigating stress-induced cognitive deficits.
  • Melatonin's effectiveness in cognitive enhancement under stress is dose-dependent.
  • Choline alphoscerate did not show a significant benefit for cognitive function in this stress model.