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Updated: May 25, 2025

Author Spotlight: Advancing Bioimaging and Therapy with Functional Nanomaterials

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Published on: September 13, 2024

Polylactic Acid (PLA)-Based Persistent Room-Temperature Phosphorescence Polymer Nanoparticles for Bioimaging.

Kaimin Zhang¹, Danman Guo¹, Tianyi Tang¹

¹PCFM Lab, GETRC for High-performance Organic and Polymer Photoelectric Functional Films, GBRCE for Functional Molecular Engineering, IGCME, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China.

ACS Applied Materials & Interfaces

|February 26, 2025

Summary

This summary is machine-generated.

New polymeric nanoparticles embed persistent room-temperature phosphorescence (pRTP) molecules in a biocompatible matrix. This approach enables effective in vivo imaging with reduced phosphorescent material, enhancing biomedical applications.

Keywords:

bioimaging microemulsion persistent phosphorescence polylactic acid polymer nanoparticles

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Area of Science:

Biomaterials Science
Nanotechnology
Medical Imaging

Background:

Developing nanoscale persistent room-temperature phosphorescence (pRTP) structures is crucial for biomedical applications.
Traditional pRTP nanoparticles often use non-biocompatible emitters at high concentrations.
There is a need for safer and more efficient pRTP systems for biological use.

Purpose of the Study:

To develop novel polymeric pRTP nanosystems using a biocompatible matrix.
To reduce the concentration of phosphorescent molecules required for effective pRTP.
To evaluate the biocompatibility, stability, and in vivo imaging capabilities of the new nanosystems.

Main Methods:

Fabrication of polymer nanoparticles using a poly(lactic acid) (PLA) matrix via a microemulsion-based method.
Embedding persistent room-temperature phosphorescence (RTP) molecules within the PLA matrix.
Characterization of pRTP properties, including phosphorescence lifetime and concentration dependence.
Assessment of biocompatibility, stability, and in vivo imaging performance.

Main Results:

Polymeric pRTP nanoparticles demonstrated comparable long-lasting phosphorescence (118 ms lifetime) to traditional nanoparticles.
Effective pRTP was achieved with phosphorescent molecule content below 2%.
The nanoparticles exhibited excellent biocompatibility, stability, and reversible photoactivated pRTP properties.
Successful in vivo imaging was achieved with a high signal-to-noise ratio (2061) and sustained emission for 20 minutes.

Conclusions:

Polymeric pRTP nanosystems offer a promising alternative to traditional pRTP nanoparticles for biomedical applications.
Embedding RTP molecules in a biocompatible polymer matrix significantly reduces required concentrations while maintaining performance.
These novel nanosystems demonstrate potential for advanced in vivo imaging and other biological applications.